PPIAL4A
peptidylprolyl isomerase A like 4A
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Located in extracellular exosome.
provided by Alliance of Genome Resources
Biological Domains
Proteostasis
Pharos Class
Tdark
Summary of Evidence
This tab shows an overview of how the selected gene is associated with AD.
Genetic Association with LOAD
Indicates whether or not this gene shows significant genetic association with Late Onset AD (LOAD) based on evidence from multiple studies compiled by the ADSP Gene Verification CommitteeFalseBrain eQTL
Indicates whether or not this gene locus has a significant expression Quantitative Trait Locus (eQTL) based on an AMP-AD consortium studyFalseRNA Expression Change in AD Brain
Indicates whether or not this gene shows significant differential expression in at least one brain region based on AMP-AD consortium work. See ‘EVIDENCE’ tab.No dataProtein Expression Change in AD Brain
Indicates whether or not this gene shows significant differential protein expression in at least one brain region based on AMP-AD consortium work. See ‘EVIDENCE’ tab.FalseNominated Target
Indicates whether or not this gene has been submitted as a nominated target to Agora.False
AD Risk Scores
About AD Risk Scores
The TREAT-AD Center at Emory-Sage-SGC has developed a Target Risk Score (TRS) to objectively rank the potential involvement of specific genes in AD. The TRS is derived by summing two component risk scores, the Genetic Risk Score and the Multi-omic Risk Score, each of which is derived from a meta-analysis of multiple harmonized data sets. More information about the methodology used to define these risk scores is available here.
AD Risk Scores for PPIAL4A
The TRS for PPIAL4A, along with the component Genetic and Multi-omic Risk Scores, is shown here. The scores for PPIAL4A are superimposed on the genome-wide score distributions. If No Data is Currently Available is displayed for a score, that score was not calculated for PPIAL4A.
Biological Domain Classification
About Biological Domains
A biological domain represents a standardized area of biology defined by a set of discrete, biologically coherent GO terms. The TREAT-AD Center at Emory-Sage-SGC has defined nineteen biological domains associated with AD, and objectively mapped genes to those biological domains using GO term annotations. More information about the methodology used to define AD biological domains, and to generate genome-wide biological domain mappings, is available here.
Biological Domains for PPIAL4A
Select a biological domain on the left to see the list of GO terms that link PPIAL4A to it on the right. The percentage value displayed next to the currently selected biological domain indicates the proportion of PPIAL4A's total unique GO terms that map to the biological domain. The ratio displayed on the right indicates how many of the biological domain's total GO terms PPIAL4A is annotated with.